氏名：千住 覚（せんじゅう さとる）
所属：熊本大学大学院医学薬学研究部 先端生命医療科学部門 感染・免疫学講座 免疫識別学分野
受賞：財団法人 武田科学振興財団 2006年度 医学系研究奨励金
日本組織適合性学会 平成17年度 学術奨励賞最優秀賞「ES細胞から分化誘導した樹状細胞を用いたMHC拘束性T細胞応答制御技術の開発」
財団法人 金原一郎記念医学医療振興財団 第20回 基礎医学医療研究助成金（平成17年度）
平成15年度 熊本医学会奨励賞
東京生化学研究会研究奨励金（平成12年度）
所属学会：日本免疫学会、日本癌学会、日本組織適合性学会、日本がん免疫学会
発表論文
Senju, S., Haruta, M., Matsunaga, Y., Fukushima, S., Ikeda, T., Takahashi, K., Okita, K., Yamanaka, S., and Nishimura, Y. Characterization of dendritic cells and macrophages generated by directed differentiation from mouse induced pluripotent stem cells.
Stem Cells in press.
Fukushima, S., Hirata, S., Motomura, Y., Fukuma, D., Matsunaga, Y., Ikuta, Y., Ikeda, T., Kageshita, T., Ihn, H., Nishimura, Y., and Senju, S. Multiple antigen-targeted immunotherapy with a-galactosylceramide-loaded and genetically engineered dendritic cells derived from embryonic stem cells.
J.Immunotherapy in press.
Ikuta, Y., Hayashida, Y., Hirata, S., Irie, A., Senju, S., Kubo, T., Nakatsura, T., Monji, M., Sasaki, Y., Baba, H., and Nishimura, Y. (*These two authors contributed equally.) : Identification of the H2-Kd-restricted CTL epitopes of a tumor-associated antigen, SPARC, which can stimulate antitumor immunity without causing autoimmune disease in mice.
Cancer Science 100: 132-137, 2009.
Matsunaga, Y., Fukuma, D., Hirata, H., Fukushima, S., Haruta, M., Ikeda, T., Negishi, I., Nishimura, Y. and Senju, S.: Activation of antigen-specific CTL by beta 2-microglobulin or TAP1 gene-disrupted and recipient-matched MHC class I gene-introduced allogeneic ES cell-derived dedritic cells.
J.Immunol.181: 6635-6643, 2008
Harao, M., Hirata, S., Irie, A., Senju, S., Nakatsura, T., Komori, H., Ikuta, Y., Yokomine, K., Imai, K., Inoue, M., Harada, K., Mori, T., Tsunoda, T., Nakatsuru, S., Daigo, Y., Nomori, H., Nakamura, Y., Baba, H., Nishimura, Y. HLA-A2-restricted CTL epitopes of a novel lung cancer-associated cancer testis antigen, cell division cycle associated 1, can induce tumor-reactive CTL.
Int. J. Cancer, 123: 2616-2625, 2008.
Imai, K., Hirata, S., Irie, A., Senju, S., Ikuta, Y., Yokomine, K., Harao, M., Inoue, M., Tsunoda, T., Nakatsuru, S., Nakagawa, H., Nakamura, Y., Baba, H., and Nishimura, Y. Identification of a novel tumor-associated antigen, Cadherin 3/P-cadherin, as a possible target for immunotherapy of pancreatic, gastric and colorectal cancers.
Clin. Cancer Res 14: 6487-6495, 2008.
Tsukamoto, H., Irie, A., Senju, S., Hatzopoulos, A.K., Wojnowski, L.and Nishimura, Y. B-Raf-mediated signaling pathway regulates T cell development.
Eur. J. Immunol. 38: 518-527, 2008.
Senju, S., Suemori, H., Zembutsu, H., Uemura, Y., Hirata, S., Fukuma, D., Matsuyoshi, H., Shimomura, M., Haruta, M., Fukushima, S., Matsunaga, Y., Katagiri, T., Nakamura, Y., Furuya, M., Nakatsuji, N., and Nishimura, Y. Genetically manipulated human embryonic stem cell-derived dendritic cells with immune regulatory function.
Stem cells 25: 2720-2729, 2007.
Yokomine, K., Nakatsura, T., Senju, S., Nakagata, N., Minohara, M, Kira, J., Motomura, Y., Kubo, T., Sasaki, Y., and Nishimura, Y. Regression of intestinal adenomas by vaccination with heat shock protein 105-pulsed bone marrow-derived dendritic cells in ApcMin/+ mice.
Cancer Science 98: 1930-1935, 2007.
Hirata, S., Matsuyoshi, H., Fukuma, D., Kurisaki, A., Uemura, Y., Nishimura, Y.* and Senju, S.* (*equal contribution): Involvement of regulatory T cells in the experimental autoimmune encephalomyelitis- preventive effect of dendritic cells expressing myelin oligodendrocyte glycoprotein plus TRAIL.
J. Immunol. 178: 918-925, 2007.
Komori, H., Nakatsura, T., Senju, S., Ikuta, Y., Yokomine, K., Yoshitake, Y., Motomura, Y., Beppu, T., Matsui, M., Torigoe, T., Sato, N., Baba, H.and Nishimura, Y. Identification of HLA-A2- or HLA-A24-restricted CTL epitopes possibly useful for glypican-3-specific immunotherapy of hepatocellular carcinoma.
Clin. Cancer Res.12: 2689-2697, 2006.
Motomura, Y., Senju, S., Nakatsura, T., Matsuyoshi, H., Hirata, S., Monji, M., Komori, H., Fukuma, D., Baba, H., and Nishimura, Y.: Embryonic stem cell-derived dendritic cells expressing Glypican-3, a recently identified oncofetal antigen, induce protective immunity against highly metastatic mouse melanoma, B16-F10.
Cancer Research66: 2414-2422, 2006.
Hirata, S., Senju, S., Matsuyoshi, H., Fukuma, D., Uemura, Y. and Nishimura, Y. Prevention of experimental autoimmune encephalomyelitis by transfer of embryonic stem cell-derived dendritic cells expressing myelin oligodendrocyte glycoprotein peptide along with TRAIL or programmed death-1 ligand1.
J. Immunol.(IF=6.5) 174: 1888-1897, 2005.
Fukuma, D., Matsuyoshi, H., Hirata, S., Kurisaki, A., Yoshitake, Y., Sinohara, M., Nishimura, Y., and Senju, S. Cancer prevention with semi-allogeneic ES cell-derived dendritic cells.
Biochem. Biophys. Res. Comm. 335: 5-13, 2005.
Miyazaki, M.*, Nakatsura, T.*, Senju, S., Monji, M., Hosaka, S., Komori, H., Yoshitake, Y., Motomura, Y., Yokomine, K., Minohara, M., Kubo, T., Ishihara, K., Hatayama, T., Ogawa, M., and Nishimura, Y. (*equal contribution): DNA vaccination of HSP105 leads to tumor rejection of colorectal cancer and melanoma in mice through activation of both CD4+T cells and CD8+ T cells.
Cancer Science 96: 695-705, 2005.
Matsuyoshi, H., Hirata, S., Yoshitake, Y., Motomura, Y., Fukuma, D., Kurisaki, A., Nakatsura, T., Nishimura, Y., and Senju, S. Therapeutic effect of a-galactosylceramide-loaded dendritic cells genetically engineered to express SLC/CCL21 along with tumor antigen against peritoneally disseminated tumor cells.
Cancer Science 96: 889-896, 2005.
Guo , Y., Niiya, H., Azuma, T., Uchida, N., Yakushijin Y., Sakai, I., Hato, T., Takahashi, M., Senju, S., Nishimura, Y. and Yasukawa M. : Direct recognition and lysis of leukemia cells by WT1-specific CD4+ T lymphocytes in an HLA class II-restricted manner.
Blood 106: 1415-1418, 2005.
Yano, T., Yamada, K., Kimura, A., Takeshita, T., Minohara, M., Kira, J-I, Senju, S., Nishimura, Y., and Tanihara, H.: Autoimmunity against neurofilament protein and its possible association with HLA-DRB1*1502 allele in glaucoma.
Immnol. Lts. 100: 164-169, 2005.
Ohkura, T., Taniguchi, S.,Yamada, K., Nishio, N., Okamura, T., Yoshida, A., Kamijou, K., Fukata, S., Kuma, K., Inoue, Y., Hisatome, I., Senju, S., Nishimura Y., and Shigemasa, C. Detection of the novel autoantibody (anti-UACA antibody) in patients with Graves? disease.
Biochem. Biophys. Res. Comm. 321: 432-440, 2004.
Matsuyoshi, H., Senju, S., Hirata, S., Yoshitake, Y., Fukuma, D., Motomura,Y. ,and Nishimura, Y. : Cancer immunotherapy by genetically modified embryonic stem cell-derived dendritic cells.
Immunology 2004. The proceeding of the 12th International Congress of Immunology, ed. By Skamene, E. and Medimond S.r.l. (Bologna, Italy), p487-491, 2004.
Nakatsura, T., Kageshita, T., Ito, S., Wakamatsu, K., Monji, M., Ikuta, Y., Senju, S., Ono, T. and Nishimura, Y. Identification of glypican-3 as a novel tumor marker for melanoma.
Clin. Cancer Res. 10: 6612-6621, 2004
Monji, M., Nakatsura, T., Senju, S., Yoshitake, Y., Sawatsubashi, M., Shinohara, M., Kageshita, T., Ono, T., Inokuchi, A. and Nishimura, Y. Identification of a novel cancer/testis antigen, KM-HN-1, recognized by cellular and humoral immune responses.
Clin. Cancer Res. 10: 6047-6057, 2004
Yoshitake, Y., Nakatsura, T., Monji, M., Senju, S., Matsuyoshi, H., Tsukamoto, H., Hosaka, S.,Komori, H., Fukuma, D., Ikuta, Y., Katagiri, T., Furukawa, Y., Itoh, H., Shinohra, M., Nakamura, Y.,and Nishimura, Y.: Proliferation potential-related protein, an ideal esophageal cancer antigen for immnotherapy, identified using cDNA microarray analysis.
Clinical Cancer Res. 10: 6437-6448, 2004
Matsuyoshi, H., Senju, S., Hirata, S., Yoshitake, Y., Uemura, Y., and Nishimura, Y. Enhanced priming of antigen-specific CTL in vivo by transfer of ES cell-derived dendritic cells expressing chemokine along with antigenic protein；application to anti-tumor vaccination.
J. Immunol. 172: 776-786, 2004
Senju S, Matsuyoshi H, Hirata S, and Nishimura Y. Cellular vaccination with genetically modified dendritic cells derived from mouse ES cells.
J. Invest. Dermatol. 121: 1241, 2003.
Uemura, Y., Senju, S., Fujii, S., Iwai, L.K., Maenaka, K., Tabata, H., Kanai, T., Chen, Y-Z. and Nishimura, Y. [Review] Specificity, degeneracy, and molecular mimicry in antigen recognition by HLA-class II restricted T cell receptors; implications for clinical medicine.
Modern Rheumatology 13: 205-214, 2003.
Nakatsura, T., Yoshitake, Y., Senju, S., Monji, M., Komori, H., Motomura, Y., Hosaka, S., Beppu, T., Ishiko, T., Kamohara, H., Ashihara, H., Katagiri, T., Furukawa, Y., Fujiyama, S., Ogawa, M., Nakamura, Y., and Nishimura, Y. Glypican-3, overexpressed specifically in human hepatocellular carcinoma, is a novel tumor marker.
Biochem. Biophys. Res. Comm. 306: 16-25, 2003
Kai, M., Nakatsura, T., Egami, H., Senju, S., Nishimura, Y., and Ogawa, M. Heat shock protein 105 is overexpressed in a variety of human tumors.
Oncology reports 10: 1777-1782, 2003
Nakatsura,T., Monji, M., Senju, S., Yamada, K., Ogawa, M., Nishimura, Y. Identification of cancer antigens by SEREX.
Int. Congress Series 1255: 343-349, 2003
Kobayashi, H., Omiya, R., Sodey, B., Yanai, M., Oikawa, K., Sato, K., Kimura, S., Senju, S., Nishimura, Y., Tateno, M., Celis, E. Identification of Naturally Processed Helper T-Cell Epitopes from Prostate-Specific Membrane Antigen Using Peptide-Based in Vitro Stimulation
Clinical Cancer Research 9: 5386-5393, 2003
Senju, S., Hirata, S., Matsuyoshi, H., Masuda, M., Uemura, Y., Araki, K., Yamamura, K-I., and Nishimura, Y. Generation and genetic modification of dendritic cells derived from mouse embryonic stem cells.
Blood 101: 3501-3508, 2003
Uemura, Y., Senju, S., Maenaka, K., Iwai, L. K., Fujii, S., Tabata, H., Tsukamoto, H., Hirata, S., Chen, Y-Z., and Nishimura, Y. Systematic Analysis of the Combinatorial Nature of Epitopes Recognized by TCR Leads to Identification of Mimicry Epitopes for GAD65 Specific TCRs.
J. Immunol. 170: 947-960, 2003
Monji, M., Senju, S., Nakatsura, T., Yamada, K., Sawatsubashi, M., Inokuchi, A., and Nishimura Y. Head and neck cancer antigens recognized by the humoral immune system
Biochem. Biophys. Res. Commun. 294: 734-741, 2002
Nakatsura, T., Senju, S., Ito, M., Nishimura, Y.*, and Itoh, K.* (*equal contribution). Cellular and Humoral Immune Responses to A Human Pancreatic Cancer Antigen, CLP, Originally Defined by the SEREX Method
Eur. J. Immunol. 32: 826-836, 2002
Masuda, M., Senju, S., Fujii, S., Terasaki, Y., Takeya, M., Hashimoto, S., Matsushima, K., Yumoto, E., and Nishimura, Y. Identification and Immunocytochemical Analysis of DCNP1, a Dendritic Cell-Associated Nuclear Protein.
Biochem. Biophys. Res. Commun. 290: 1022-1029, 2002.
Yamada, K., Senju, S., Shinohara, T., Nakatsura, T., Murata, Y., Ishihara, M., Nakamura, S., Ohno, S., Negi, A., and Nishimura, Y. Humoral immune response directed against LEDGF in patients with VKH.
Immunol. Lettrs 78: 161-168, 2001
Fujii, S*., Uemura, Y*., Iwai, L. K., Ando, M., Senju, S., and Nishimura., Y. (*equal contribution) Establishment of an expression cloning system for CD4+ T cell epitopes.
Biochem. Biophys. Res. Commun. 284: 1140-1147, 2001.
Yamada, K., Senju, S., Nakatsura, T., Murata, Y., Ishihara, M., Nakamura, S., Ohno, S., Negi, A., and Nishimura, Y. Identification of a Novel Autoantigen UACA in Patients with Panuveitis.
Biochem. Biophys. Res. Commun. 280: 1169-1176, 2001.
Nakatsura, T., Senju, S., Yamada, K., Jotsuka, T., Ogawa, M., and Nishimura, Y. Gene cloning of immunogenic antigens over-expressed in pancreatic cancer.
Biochem. Biophys. Res. Commun. 281: 936-944, 2001.
Kudo, H.,. Senju, S., Mitsuya, H., and Nishimura, Y. Mouse and human GTPBP2, newly identified members of the GP-1 family of GTPase.
Biochem. Biophys. Res. Commun. 272: 456-465, 2000.
Senju, S., Iyama, K., Kudo, H., ,Aizawa, S., and Nishimura, Y. Immunocytochemical analyses and trageted gene disruption of GTPBP1.
Mol. Cell. Biol. 20: 6195-6200, 2000.
Yun, C., Senju, S., Fujita, H., Tsuji, Y., Irie, A., Matsushita, S., and Nishimura, Y. Augmentation of immune response by altered peptide ligands of the antigenic peptide in human CD4 T cell clone reacting to TEL/AML1 fusion protein.
Tissue Antigens 54:153-161, 1999.
Fujita, H., Senju, S., Yokomizo, H., Saya, H., Ogawa, M., Matsushita, S., and Nishimura, Y. Evidence that HLA class II-restricted human CD4+ T-cells specific to p53 self peptides respond to p53 proteins of both wild and mutant forms.
Eur. J.Immunol. 28: 305-316, 1998.
Fujii, S., Senju, S., Chen, Y-Z., Ando, M., Matsushita, S. and Nishimura, Y. The CLIP-substituted invariant chain efficiently targets an antigenic peptide to HLA class II pathway in L cell.
Human Immunol. 59: 607-614, 1998.
Senju, S. and Nishimura, Y. Identification of human and mouse GP-1, members of a novel G-protein family.
Biochem. Biophys. Res. Comm. 231: 360-364, 1997.
Kanai, T., Nomura, Y., Segawa, M., Takagi, K., Senju, S., Matsushita, S., and Nishimura, Y. Immuno-suppressive peptides for a human T cell clone autoreactive to a unique acetylcholine receptor a subunit peptide presented by the disease susceptible HLA-DQ6 in infant-onset myasthenia gravis.
Human Immunol. 56: 28-38, 1997.
Senju, S., Negishi, I., Motoyama, K., Wang, F., Nakayama, K., Nakayama, K., Hatakeyama, S., Zhang, Q., Lucas, P.J., and Loh, D.Y. Functional significance of the Fas molecule in naive lymhpocytes.
International Immunol. 8: 423-431, 1996.
Motoyama, N., Wang, F., Roth, K.A., Sawa, H., Nakayama, K., Nakayama, K., Negishi, I., Senju, S., Zhang, Q., Fujii, S., and Loh, D.Y. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice.
Science 267: 1506-1510, 1995.
Negishi, I., Motoyama, N., Nakayama, K., Nakayama, K., Senju, S., Hatakeyama, S., Zhang, Q., Chan, A.C., and Loh, D.Y. Essential role for ZAP-70 in both positive and negative selection of thymocytes.
Nature 376: 435-438, 1995.
Senju S., Kimura, A., Yasunami, M., Kamikawaji, N., Yoshizumi, H., Nishimura, Y., and Sasazuki, T. Allele-specific expression of the cytoplasmic exon of HLA-DQB1 gene.
Immunogenetics 36: 319-325, 1992.