英語版投稿 - 健康長寿代謝制御研究センター │ 熊本大学大学院生命科学研究部附属

The collaborative work by Dana-Farber Cancer Institute and Prof. Hideo BABA is published in Clinical Cancer Research.

2018-12-01

Amplification of Wild-type KRAS Imparts Resistance to Crizotinib in MET Exon 14 Mutant Non-Small Cell Lung Cancer.

Bahcall M, Awad MM, Sholl LM, Wilson FH, Xu M, Wang S, Palakurthi S, Choi J, Ivanova EV, Leonardi GC, Ulrich BC, Paweletz CP, Kirschmeier PT, Watanabe M, Baba H, Nishino M, Nagy RJ, Lanman RB, Capelletti M, Chambers ES, Redig AJ, VanderLaan PA, Costa DB, Imamura Y, Janne PA

Clin Cancer Res 24(23):5963-5976, 2018.

DOI: 10.1158/1078-0432.CCR-18-0876.

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The collaborative work by Azabu Univ. , Keio Univ. and Assoc. Prof. Kyoko MIURA is published in PNAS.

2018-08-27

Responses to pup vocalizations in subordinate naked mole-rats are induced by estradiol ingested through coprophagy of queen’s feces.

Watarai A, Arai N, Miyawaki S, Okano H, Miura K, Mogi K, Kikusui T.

DOI: 10.1073/pnas.1720530115

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The collaborative work by Univ. of California and Assoc. Prof. Toshiro MOROISHI is published in Nature.

2018-08-22

RAP2 mediates mechanoresponses of Hippo pathway

Meng Z., Qiu Y., Lin K.C., Kumar A., Placone J.K., Fang C., Wang K.C., Lu S., Pan M., Hong A.W., Moroishi T., Luo M., Plouffe S.W., Diao Y., Ye Z., Park H.W., Wang X., Yu F.X., Chien S., Wang C.Y., Ren B., Engler A.J., Guan K.L.

DOI：10.1038/s41586-018-0444-0

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The review article by Prof. Kazuya IWAMOTO is published in Molecular Psychiatry.

2018-08-07

Somatic mutations in the human brain: implications for psychiatric research

Masaki Nishioka, Miki Bundo, Kazuya Iwamoto*,Tadafumi Kato*
(*correspondence authors)

DOI:　10.1038/s41380-018-0129-y

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The collaborative work by Dana-Farber Cancer Institute and Prof. Hideo BABA is published in Nature Medicine.

2018-07-23

Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses.

Canadas I, Thummalapalli R, Kim JW, Kitajima S, Jenkins RW, Christensen CL, Campisi M, Kuang Y, Zhang Y, Gjini E, Zhang G, Tian T, Sen DR, Miao D, Imamura Y, Thai T, Piel B, Terai H, Aref AR, Hagan T, Koyama S, Watanabe M, Baba H, Adeni AE, Lydon CA, Tamayo P, Wei Z, Herlyn M, Barbie TU, Uppaluri R, Sholl LM, Sicinska E, Sands J, Rodig S, Wong KK, Paweletz CP, Watanabe H, Barbie DA

Nat Med 24(8):1143-1150, 2018.

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The work by Prof. Kazuya YAMAGATA is published in Nature Communications.

2018-07-19

SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix.

Fukuda M, Yoshizawa T, Karim Md. F, Sobuz S. U., Korogi W, Kobayasi D, Okanishi H, Masayoshi T, Ono K, Sawa T, Sato Y, Chirifu M, Masuda T, Nakamura T, Tanoue H, Nakashima K, Kobashigawa Y, Morioka H, Bober E, Ohtsuki S, Yamagata Y, Ando Y, Oike Y, Araki N, Takeda S, Mizuta H, Yamagata K.

掲載誌：Nature Communications 9, 2833 (2018)

DOI: 10.1038/s41467-018-05187-4

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The collaborative work by Univ. of California and Assoc. Prof. Toshiro MOROISHI is published in Nature Communications.

2018-07-09

Assembly and activation of the Hippo signalome by FAT1 tumor suppressor.
Martin, D., Degese, M.S., Vitale-Cross, L., Iglesias-Bartolome, R., Valera, J.L.C., Wang, Z., Feng, X., Yeerna, H., Vadmal, V., Moroishi, T., Thorne, R.F., Zaida, M., Siegele, B., Cheong, S.C., Molinolo, A.A., Samuels, Y., Tamayo, P., Guan, K.L., Lippman, S.M., Lyons, J.G., and Gutkind, J.S.
DOI：10.1038/s41467-018-04590-1

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The collaborative work by Dana-Farber Cancer Institute and Prof. Hideo BABA is published in Nature Medicine.

2018-05-28

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.

Wong GS, Zhou J, Liu JB, Wu Z, Xu X, Li T, Xu D, Schumacher SE, Puschhof J, McFarland J, Zou C, Dulak A, Henderson L, Xu P, O’Day E, Rendak R, Liao WL, Cecchi F, Hembrough T, Schwartz S, Szeto C, Rustgi AK, Wong KK, Diehl JA, Jensen K, Graziano F, Ruzzo A, Fereshetian S, Mertins P, Carr SA, Beroukhim R, Nakamura K, Oki E, Watanabe M, Baba H, Imamura Y, Catenacci D, Bass AJ

Nat Med 24(7):968-977, 2018.

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The collaborative work by Kyushu Univ. and Prof. Yuichi OIKE is published in Cell Reports.

2018-05-15

The autism-related protein CHD8 cooperates with C/EBPβ to regulate adipogenesis.

Kita Y, Katayama Y, Shiraishi T, Oka T, Sato T, Suyama M, Ohkawa Y, Miyata K, Oike Y, Shirane M, Nishiyama M, Nakayama KI.

Cell Rep. 23: 1988-2000, 2018.

doi: 10.1016/j.celrep.2018.04.050.

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Inaugural ceremony and kick-off symposium for CMHA were held on May 2, 2018.

2018-05-02

健康長寿代謝制御研究センターの発足式及びシンポジウムを５月２日に開催しました。
シンポジウムに先立ち、総合研究棟にて発足式が行われ、原田学長、安東研究部長、山縣センター長の挨拶の後、看板掲揚となりました。

発足式の後、山崎記念館においてキックオフシンポジウム「くまもとから目指す健康長寿社会」を開催しました。シンポジウムでは今井眞一郎教授（ワシントン大学）、片桐秀樹教授（東北大学）による特別講演や熊本大学における最新の老化研究の紹介が行われ、100名以上の聴衆は熱心に発表内容に耳を傾けていました。

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