Department of Developmental Neurobiology KUMAMOTO UNIVERSITY

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Website updated.
【Significance of Tsukushi in lung cancer】accepted on Lung Cancer.(Ohta)
Kumamoto - NCBS/InStem Partnership Meeting (National Centre for Biological Sciences (NCBS). Niigata University, Bangalore.India.) Introduction of our research results.(Ohta)
Joint Symposium with Molecular Neurodegeneration: Meet the Editors-in Chief. (Kumamoto University, Kumamoto ) Introduction of our research results.(Ito)
【CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi】accepted on Journal of Cell Communication and Signaling.(Ohta)
【The hepatokine Tsukushi gates energy expenditure via brown fat sympathetic innervation】accepted on Nature Metabolism.(Ohta)
Kumamoto University Research Fair.(Kumamoto University, Kumamoto ) Introduction of our research results.(Ito)
The 39th Annual Meeting of the Molecular Biology Society of Japan (MBSJ)2018. (PACIFICO Yokohama,Yokohama ) Introduction of our research results.(Ito)
Hydrocephalus Meeting 2018 (Palazzo Re Enzo,Bologna, Italy) Introduction of our research results.(Ohta)
National Institute for Physiological Sciences(NIPS)Meeting 2018(Nagoya City University Hospital, Nagoya) Introduction of our research results.(Ohta)
CREST, PRESTO, ACT-XFY 2018 (Nagoya University Institute of Transformative Bio-Molecules (ITbM), Nagoya) Introduction of our research results.(Ohta)


We found a novel secreted molecule, named Tsukushi (TSK), which belongs to SLRP family. TSK inhibits Wnt signaling and functions to maintain adult retinal stem/progenitor cells. TSK is expressed at the bulge area and regulates the hair cycle by interacting TGF-β. Now, we study the role of TSK on brain stem cells using TSK KO mice with cre-loxp system. We propose that TSK functions as a niche molecule to control stem cells proliferation.

Recently, we generated the multipotent cells by incorporating Lactic Acid Bacteria (LAB) into human dermal fibroblasts (HDF). The LAB-incorporated cells form the clusters and differentiate into the cells derived from three germ layers. We study the potential wide-ranging implications of our multipotent cells for cell generation, reprogramming, and cell-based therapy.

【research project name and summary】

T. Research on signal molecules Tsukushi,Akhirin,Equarin.
   1. Functional analysis in the cranial nerve stem cell control and hydrocephalus of Tsukushi
   2. Cranial nerve stem cell control by Akhirin
   3. Differentiation control of the lens cell by Equarin

U. Research of the re-programming mechanism of the cell due to Ribosome



Kunimasa Ohta Ph.D.
Department of Developmental Neurobiology
Graduate School of Life Sciences
Kumamoto University
1-1-1 Honjo
Kumamoto, 860-8556
JAPAN ohta9203*
  • Kumamoto Unibersity
  • Faculty of Life Sciences Kumamoto Univesity