Department of Developmental Neurobiology KUMAMOTO UNIVERSITY

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【Tsukushi is essential for proper maintenance and terminal differentiation of mouse hippocampal neural stem cells 】accepted on Development, Growth & Differentiation.(Adil)
【Akhirin affects neurogenesis at both subventricular zone and hippocampal neurogenic niches 】accepted on Development, Growth & Differentiation.(Anam)
The 42rd Annual Meeting of the Molecular Biology Society of Japan (MBSJ2019)(Fukuoka International Congress Center, Fukuoka ) Introduction of our research results.(Ohta,Ito,Arif,Kudo)
The 10th INTERNATIONAL WORKSHOP ON THE CCN FAMILY OF GENES(ICCNS).(The Marriott Fallsview Hotel NIAGARA FALLS, ONTARIO, CANADA) Introduction of our research results.(Ohta)
Jthe 56th Annual Meeting of the Japanese Society of Virology Kyushu and the 72nd Annual Meeting of the Japanese Society of Bacteria Kyushu held (Kumamoto International center, Kumamoto ) Introduction of our research results.(Ohta)
Japan Science and Technology Agency 2019.(Okazaki Conference Center, National Institutes of Natural Sciences, Okazaki ) Introduction of our research results.(Ohta)
Summer Retreat 2019 (KIKUCHI-ONSEN, Kikuchi city Kumamoto)Introduction of our research results(Ohta,Ito,Adil,Anam,Arif,Kudo,Nakayama)
the 9th Ortho-Organogenesis Meeting(YAMANAKA-ONSEN, Ishikawa ) Introduction of our research results.(Ohta)
2019 Eurogenesis Meeting (Po^le juridique et judiciaire"Bordeaux", France ) Introduction of our research results.(Ohta)
The 17th Stem Cell Research Symposium(Awaji Yumebutai International Conference Center, Awaji City, Hyogo ) Introduction of our research results.(Ohta)
52nd annual meeting of the Japanese Society of Developmental Biologists (JSDB). (Osaka International House. Osaka. ) Introduction of our research results.(Ohta, Ito, Adil, Anam, Kudo)


We found a novel secreted molecule, named Tsukushi (TSK), which belongs to SLRP family. TSK inhibits Wnt signaling and functions to maintain adult retinal stem/progenitor cells. TSK is expressed at the bulge area and regulates the hair cycle by interacting TGF-β. Now, we study the role of TSK on brain stem cells using TSK KO mice with cre-loxp system. We propose that TSK functions as a niche molecule to control stem cells proliferation.

Recently, we generated the multipotent cells by incorporating Lactic Acid Bacteria (LAB) into human dermal fibroblasts (HDF). The LAB-incorporated cells form the clusters and differentiate into the cells derived from three germ layers. We study the potential wide-ranging implications of our multipotent cells for cell generation, reprogramming, and cell-based therapy.

【research project name and summary】

T. Research on signal molecules Tsukushi,Akhirin,Equarin.
   1. Functional analysis in the cranial nerve stem cell control and hydrocephalus of Tsukushi
   2. Cranial nerve stem cell control by Akhirin
   3. Differentiation control of the lens cell by Equarin

U. Research of the re-programming mechanism of the cell due to Ribosome



Kunimasa Ohta Ph.D.
Department of Developmental Neurobiology
Graduate School of Life Sciences
Kumamoto University
1-1-1 Honjo
Kumamoto, 860-8556
JAPAN ohta9203*
  • Kumamoto Unibersity
  • Faculty of Life Sciences Kumamoto Univesity