（D）Ribosome

　Various types of bacteria live together and form an ecosystem in the bowels, which is called enteral flora. Lactic acid bacteria are human health improving bacterium which produce lactic acid by digesting sugar. These bacteria are essential for the efficacy of digestion and dermatitis. They are considered as the ‘first runner of the modern medicine’ with several other promises yet to be elucidated. Basic information such as the influence on epigenome and cell function of the intestinal epithelium cells by the lactic acid bacterium (LAB) is also hardly studied.

　We are interested to check the symbiotic relationship between the human dermal fibroblast (HDF) cells and LAB. In culture condition, the cell which incorporated a LAB formed an embryonic stem cell like cell cluster. In addition, that cell cluster also differentiated into various multipotent stem cells of differentgerml origins. Microarray analysis shows that the gene cluster are more multipotent than HDF cells evident by the expression of NANOG and is expected to increase the cell cluster. On the other hand, the HOX gene cluster which is responsible for the anterior-posterior patterning of the body, is down regulated. (Ohta et at 2012.) Currently our lab is investigating the specific reprogramming factor derived from LAB which is responsible for the generation of multipotency (Ito et al., in preparation).